Synthesis, spectroscopic characterizations and biological studies on gold(III), ruthenium(III) and iridium(III) complexes of trimethoprim antibiotic drug

Abstract

Ruthenium(III), gold(III), and iridium(III) trimethoprim drug (TMP) complexes were synthesized and analyses via microanalytical approach (C, H, N analysis), magnetic, molar conductance, and FTIR, 1H NMR, XRD, and UV-Vis spectroscopy. Through two nitrogen atoms of –NH2 amino groups, the TMP drug coordinated as a bidentate ligand towards the corresponding three metal ions. The geometrical structure of the compounds ruthenium(III), gold(III), and iridium(III) is octahedral and consists of two TMP molecules, two coordinated chlorine atoms, and one uncoordinated chlorine atom. The antibacterial properties of TMP complexes have been investigated through the use of many bacterial species, including Pseudomonas aeruginosa, Bacillus subtilis, Staphylococcus aureus, and Escherichia coli. Additionally, the generated complexes' anticancer properties against HepG-2 (human hepatocellular carcinoma) and MCF-7 (human breast cancer cell line) have been assessed. In contrast to those of clinically used antibiotics, the inhibition zone of ruthenium and iridium(III) complexes was in the low efficiency range, and the antibacterial activity of gold(III) complexes was moderate. This article discusses the possibilities and prospects for this family of metallodrugs as antibacterial or anticancer medicines. KEY WORDS: Trimethoprim drug, Chelation, Gold, TEM, XRD, FTIR Bull. Chem. Soc. Ethiop. 2024, 38(3), 701-714.                                                        DOI: https://dx.doi.org/10.4314/bcse.v38i3.12