Network pharmacology integrated molecular docking demonstrates the therapeutic mode of Panax ginseng against ovarian cancer

Abstract

Purpose: To investigate the mode of action of the active ingredients of Panax ginseng against ovarian cancer protein targets elucidated using a network pharmacology approach and molecular docking study. Methods: An integrated protein-protein interactions (PPI) network targeting ovarian cancer and P. ginseng was constructed using a network pharmacology approach and molecular docking was carried out for the active constituents of P. ginseng against the target protein of P. ginseng. Results: Ninety-six compounds were used for the molecular docking simulation against five different proteins from a PPI network of proteins linked to ovarian cancer. The protein-ligand interaction showed strong molecular interaction at the active site of the proteins (p < 0.05).Conclusion: Ginsenosides and their derivatives present in P. ginseng successfully inhibit several key enzymes and proteins associated with ovarian cancer, which may act as potential therapeutic targets for the disease.