Application of a combination of lactated Ringer's solution and ulinastatin for early resuscitation in sepsis

Abstract

Purpose: To investigate the effect of early resuscitation using a combination of lactated Ringer's solution and ulinastatin on the survival rate of patients with sepsis. Methods: 82 patients with septic shock admitted to Xi'an People's Hospital, China from June 2017 to December 2020 were enrolled and randomly divided into control and study groups (n = 41 each). Patients in control group were given conventional fluid resuscitation and anti-infective therapy, while patients in study group were additionally given ulinastatin. Acute physiology and chronic health evaluation (APACHE II) score, sequential organ failure assessment (SOFA) score, and tissue perfusion were determined. Also, mechanical ventilation time, intensive care unit (ICU) stay time, and 28-day mortality rates were recorded. Results: Both groups presented no significant difference in clinical characteristics before treatment. After treatment, APACHE II score, SOFA score, and lactic acid level of the study group significantly decreased (p < 0.05), and the patients’ condition improved. Moreover, inflammation-related indices, viz, procalcitonin (PCT), white blood cells (WBC), and C reactive protein (CRP) were significantly reduced in the study group (p < 0.05). Renal function-related indices which include creatinine, and blood urea nitrogen (BUN) significantly decreased in study group (p < 0.05). Mechanical ventilation time, and ICU stay time were significantly shortened (p < 0.0001), while short-term survival rate significantly improved (p < 0.05). Conclusion: Lactated Ringer's solution in combination with ulinastatin expedites tissue perfusion and recovery, suppresses inflammation, enhances renal function, and significantly enhances the survival rate of septic patients. These findings provide valuable information for exploring new therapeutic approaches to sepsis.