A higher risk for melanoma in patients with Parkinson’s disease: Based on the results from National Health and Nutrition Examination Survey 2001 – 2004

Abstract

The relationship between Parkinson’s disease (PD) and melanoma has been controversial. The present study used data from the 2001 – 2004 National Health and Nutrition Examination Survey database. This study included individuals aged ≥20 years with complete data on PD and melanoma, in which 48 participants were comorbid with the melanoma group, and 5774 were not. Both univariate and multivariate logistic regression analyses were conducted to investigate the connection. There was a higher proportion of PD in the melanoma group than in the non-melanoma group (2.45% vs. 0.30%). Univariate logistic regression analysis revealed that individuals with PD had an 8.32-fold higher risk of developing melanoma than those without PD. In addition, PD was significantly correlated with melanoma (OR, 8.747; 95% CI, 1.264 – 60.506; p = 0.030) after controlling for covariates in multivariate analysis. In conclusion, our research indicates a significant correlation between PD and melanoma in American adults.