Carquinostatin B, a New Neuronal Cell-protecting Substance Produced byStreptomyces exfoliatus

Author:

Shin-ya Kazuo,Kunigami Toshihiro,Kim Jun-Sik,Furihata Kazuo,Hayakawa Yoichi,Seto Haruo

Publisher

Oxford University Press (OUP)

Subject

Organic Chemistry,Molecular Biology,Applied Microbiology and Biotechnology,General Medicine,Biochemistry,Analytical Chemistry,Biotechnology

Reference2 articles.

1. mp 142–144°C; UV nm (ε) in MeOH: 230 (32,200), 267 (29,700), 425 (5,400); in MeOH + NaOH: 242 (30,400), 287 (28,000), 470 (8,100); IR (KBr): 3450, 3220, 1660 (sh), 1640 (sh), 1615cm−1; [α]Dcould not be measured since the visual absorption was too great.

2. C24H27NO4: HRFAB-MS [(M + H)+,m/z394.1970 (−4.8 mmu error)];1H-NMR (CDC13)δ:10.0 (9-NH, br.s), 7.92 (5-H, br.s), 7.20 (8-H, d, 8 Hz), 7.08 (7-H, dd, 8, 1 Hz), 5.33 (15-H, br.t, 7.5 Hz), 4.93 (10-H, d, 9 Hz), 4.15 (11-H, dq, 9, 6 Hz), 3.43 (14-H, d, 7.5 Hz), 2.07 (13-H, s), 1.77 (methyl proton assignable to dimethylketal, s), 1.74 (17, 18-H, 6H, br.s), 1.58 (methyl proton assignable to dimethylketal, s), 1.39 (12-H, d, 6 Hz).

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