Serum Digoxin Concentrations and Outcomes in Patients with Heart Failure and Atrial Fibrillation: A Single-Center Observational Study

Author:

HIRAI Toshinori1,NAGANUMA Miyoko2,SHIGA Tsuyoshi34,ECHIZEN Hirotoshi5,ITOH Toshimasa1,HAGIWARA Nobuhisa4

Affiliation:

1. Department of Pharmacy, Tokyo Women's Medical University Medical Center East, Tokyo, Japan

2. Department of Pharmacy, International University of Health and Welfare Atami Hospital, Atami, Japan

3. Department of Clinical Pharmacology and Therapeutics, The Jikei University School of Medicine, Tokyo, Japan

4. Department of Cardiology, Tokyo Women's Medical University, Tokyo, Japan

5. Meiji Pharmaceutical University, Kiyose, Japan

Publisher

Japanese Society of Clinical Pharmacology and Therapeutics

Subject

Pharmacology (medical),Pharmacology

Reference23 articles.

1. 1) Gheorghiade M, Adams KF Jr, Colucci WS. Digoxin in the management of cardiovascular disorders. Circulation. 2004; 109 (24) : 2959-64. doi: 10.1161/01.CIR.0000132482.95686.87.

2. 2) Ponikowski P, Voors AA, Anker SD, Bueno H, Cleland JGF, Coats AJS, et al. 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure: The Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology (ESC) Developed with the special contribution of the Heart Failure Association (HFA) of the ESC. Eur Heart J. 2016; 37 (27) : 2129-200. doi: 10.1093/eurheartj/ehw128.

3. 3) January CT, Wann LS, Alpert JS, Calkins H, Cigarroa JE, Cleveland JC Jr, et al. 2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines and the Heart Rhythm Society. Circulation. 2014; 130 (23) : 2071-104. doi: 10.1161/CIR.0000000000000040.

4. 4) Ouyang AJ, Lv YN, Zhong HL, Wen JH, Wei XH, Peng HW, et al. Meta-analysis of digoxin use and risk of mortality in patients with atrial fibrillation. Am J Cardiol. 2015; 115 (7) : 901-6. doi: 10.1016/j.amjcard.2015.01.013.

5. 5) Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, et al. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016; 37 (38) : 2893-962. doi: 10.1093/eurheartj/ehw210.

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