Overview on Gastrointestinal Stromal Tumor; A Review

Author:

Abood Hashem Bark Awadh,Albalawi Amani Nasser D.,AlEnazi Haifa Obedullah,Almuhanna Mousa Mutlaq,Busaad Norah Othman,Jarad Rafa Ghazi Ali,Alkhamis Mahdi Saleh,Alsharif Shahad Majed,Alahdal Mutaz Abdulrahman S.,Alqahtani Deena Ahmed S.,Alhakamy Abdulmajeed Ramzy,Alraqibah Sulaiman Abdullah

Abstract

GISTs (gastrointestinal stromal tumours) are benign tumours that most usually affect the gastrointestinal (GI) system. GISTs can strike at any age, however they are most typically diagnosed in later life, with a median diagnostic age in the 60s. Abdominal ultrasound, CT scan, magnetic resonance imaging (MRI), and positron emission transverse tomography (PET) can all be used to detect GISTs (PET).CT enterography is the most effective method for determining the location of these tumors. Histopathology and immunochemistry are used to diagnose GISTs. Surgical excision remains the therapy of choice for gastrointestinal stromal tumours more than 2 cm that are readily resectable. Due to the possibility of resistance to standard treatment, mutational analysis should be undertaken when considering adjuvant and neoadjuvant  therapy. In this review we’ll be looking at the disease etiology, epidemiology, diagnosis and management.

Publisher

Sciencedomain International

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