Study of Association of AgNOR vs Ki-67 in Thyroid Lesions

Abstract

The thyroid is an important endocrine gland, which plays a major role in the functions of almost all normal metabolic processes. In present study, by focusing the sections at very high magnification (100x, oil immersion level) AgNOR dots are visible as black dots inside the nucleus. Our studies which have reported that thyroid lesions with less AgNOR counts are more likely to regress as compared to those with high AgNOR counts and that showed its prognostic significance. Thus, the AgNOR technique can be useful as a supportive tool in both the prognosis and therapeutic value in thyroid lesions most commonly in malignant lesions that are stained by routinely performed haematoxylin and eosin. The Present Study is aim to find out the prevalence of thyroid lesions in the patients and also to Study and find out the different types of neoplastic and non- neoplastic thyroid lesions and their relation with AgNOR and Ki-67 proliferation makers. The Present Study focuses on to evaluate the association of AgNOR vs Ki-67 in the prognostic value of thyroid lesions.