Toxicological Effects of Antituberculosic Chemotherapy in Adults: An Integrative Literature Review
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Published:2021-04-07
Issue:
Volume:
Page:50-65
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ISSN:2456-9119
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Container-title:Journal of Pharmaceutical Research International
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language:
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Short-container-title:JPRI
Author:
Aguiar Viviane Ferraz Ferreira de,Carvalho Dayara de Nazaré Rosa de,Bendelaque Dandara de Fátima Ribeiro,Neves Lorena Nayara Alves,Sobrinho Celice Ruanda Oliveira,Rocha Paula Sousa da Silva,Costa Rafael Everton Assunção Ribeiro da,Nascimento Cidianna Emanuelly Melo do,Souza Susi dos Santos Barreto de,Dergan Marcela Raissa Asevedo,Brito Mioni Thieli Figueiredo Magalhães,Quaresma Juarez Antônio Simões
Abstract
Objective: To analyze the toxicological effects of anti-tuberculosis chemotherapy in adults in national and international literature in the period from 2015 to 2020.
Methodology: It is a qualitative descriptive research, of the type Integrative Literature Review (ILR). In the VHL databases PubMed / Medline, Arca, Web of Science, Microsoft Academic and Cochrane Library. Data analysis was performed with the aid of the IRaMuTeQ software.
Results: 36 articles were found in which the following categories were created: 1) Association of hepatotoxicity and appearance of liver damage; 2) The incidence of adverse events related to antituberculin therapy; 3) Risk factors of regular consumption of antituberculins; 4) Intensive renal treatment for patients with nephrotoxicity.
Conclusion: in our review we identified that the elderly, HIV positive and alcohol users are more likely to have toxicological effects during treatment, which can lead to a possible abandonment of treatment.
Publisher
Sciencedomain International