Study of Clinical Profile of Carcinoma Breast and Prognostic Significance of Serum Lactate Dehydrogenase as Tumor Marker in Carcinoma Breast

Abstract

Background: Breast cancer is the highly prevalent malignancy and is a major killer in women around world. In India, there is substantial statistically significant increase in breast cancer incidence patterns. Women from under developed areas(883000 cases) have a significantly higher no. of cases than those from developed areas (794,000) [1]. There are various risk factors associated with breast malignancy. A variety of bio-chemical markers have been tested to determine the malignancy, for the early detection of carcinoma of different origin. LDH is the easiest and cheapest to calculate of all of these indicators. Objectives: To study the clinical profile of patient with breast To study the prognostic significance of LDH as tumor marker in breast To compare post-operative LDH level in patient undergoing surgery for carcinoma breast v/s patient undergoing neoadjuvant chemotherapy. Compare variation in preoperative baselines LDH levels and post-operative LDH levels. Methodology: It is a prospective observational study done on patients with breast cancer. It will be conducted at Dept. of General Surgery , J.N.M.C and AVBRH, Sawangi (Meghe), Wardha. The study will be conducted on patients with Carcinoma Breast. Results: To be assessed after the study. Conclusion: Serum LDH is a good prognostic marker of breast cancer.