Evaluation of COX-2 Inhibitor Injurious Effects on Proximal Convoluted Tubular Diameter of Kidney with Favorable Impact of Lycopene in Albino Rats on the Basis of Microscopic Features
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Published:2021-10-27
Issue:
Volume:
Page:462-468
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ISSN:2456-9119
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Container-title:Journal of Pharmaceutical Research International
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language:
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Short-container-title:JPRI
Author:
Sundus Sadia,Hassan Aisha,Kumar Ashok,Jabeen Shah,Hameed Nadira,Ajaz Madiha
Abstract
Objective: To analyze the harmful effect of COX-2 inhibitor on proximal convoluted tubular diameter of kidney, amendment by lycopene.
Research Design: Experimental Research.
Abode of Research: Animal House, JPMC, Karachi.
Materials and Methods: 90-120 days old, forty healthy adult male Albino rats of 200-220gm weight were taken for this study and distributed into 4 cliques, set 1was chosen as control, in Set 2 Celecoxib was given 0.05g/1000g by gavage, in set 3 Celecoxib was given0.05g/1000g by gavage with lycopene 0.05g/1000g by gavage and set4 lycopene was given0.05g/1000g by gavage for 30 days. At accomplishment of study, animals were sacrifice and tissues were preserved for staining.
Results: Inset 2 proximal convoluted tubular diameter became distended due to apoptosis of lining epithelial cells. They turn into low cuboidal from simple cuboidal cells along with ill-defined brush border at the luminal surface due to scarce microvilli and had disrupted basement membrane, however renal structure were amended in set3 which were given celecoxib with lycopene.
Conclusion: This study reveals that lycopene amended the apoptotic changes of set2.
Publisher
Sciencedomain International