Comparative Study of Malondialdehyde, Superoxide Dismutase and Glutathione Peroxidase in Urolithiasis Patients: A Case Control Study

Abstract

Background: Urolithiasis i.e. stone firming disease in the urinary passages is one of the frequently encountered diseases in man. Perhaps the disease is as ancient as the man himself as has been revealed by the archaeological excavation done in different parts of the world such as in Egypt. Aim: Comparative Study of Malondialdehyde, Superoxide Dismutase and Glutathione Peroxidase in Urolithiasis Patients: A Case Control Study Materials and Methods: The study was carried out in the Department of Biochemistry, Datta Meghe Medical College Nagpur in collaboration with Department of Surgery, Division of Urology and Department of Pharmacology. Results: The urolithiasis patients have shown a marked increase in plasma MDA levels. There was a significant increase in the values of superoxide dismutase in patients suffering from urolithiasis (6.26 ± 0.86 µmol/l RBC lysate) as compared to the normal control values (3.40 ± 1.09 µmol/l RBC lysate) in human volunteers (p<0.01).A significantly decreased value of glutathione peroxidase has been observed in patients suffering from urolithiasis as compared to the control group. Conclusion: Enhanced SOD can reduce the formation of Calcium Oxalate crystals and reduce the damage of renal tubular epithelial cell.