Antifungal Activity of Flavonoid Isolated from Lindernia crustacea (L) F. Muell against Traditionally Claimed Dermatophytes

Abstract

Aim: The present study was aimed to establish antifungal activity of flavonoid isolated from Lindernia crustacea (L) F. Muell. Methods: Potent bioactive constituent from benzene extract was isolated through flash chromatography with solvent Toluene and Acetic acid (4:1). Isolated compound was structurally established by spectroscopic method. Antifungal potential of benzene extract as well as isolated compound was tested by disc diffusion method against two fungal strains Candida albicans (C. albicans) and Trichophyton rubrum (T. rubrum). Results: The isolated compound from benzene extract was found to be flavonoid. Benzene extract as well as flavonoid were shown remarkable zone of inhibition against both fungal strains which indicates strong antifungal activity. Conclusion: The experimental results concluded that Lindernia crustacea (L) F. Muell have significant anti fungal activity due to flavonoid content. It is expected that the results of the present research work would be beneficial in establishing the scientific basis of the traditional claims of medicinal values of Lindernia crustacea.