Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications-Reference-Cited by-同舟云学术

Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications

Published:2014-03 Issue:4 Volume:6 Page:385-412
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Vardanyan Ruben S¹,Hruby Victor J²

Affiliation:

1. Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85721, USA.

2. Department of Chemistry & Biochemistry, University of Arizona, Tucson, AZ 85721, USA

Abstract

Fentanyl and its analogs have been mainstays for the treatment of severe to moderate pain for many years. In this review, we outline the structural and corresponding synthetic strategies that have been used to understand the structure–biological activity relationship in fentanyl-related compounds and derivatives and their biological activity profiles. We discuss how changes in the scaffold structure can change biological and pharmacological activities. Finally, recent efforts to design and synthesize novel multivalent ligands that act as mu and delta opioid receptors and NK-1 receptors are discussed.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.13.215

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