Integration of metabolomics in heart disease and diabetes research: current achievements and future outlook

Author:

Dunn Warwick B1234,Goodacre Royston34,Neyses Ludwig256,Mamas Mamas1256

Affiliation:

1. Centre for Advanced Discovery & Experimental Therapeutics (CADET), Central Manchester NHS Foundation Trust, University of Manchester, Manchester Academic Health Sciences Centre; York Place, Oxford Road, Manchester, M13 9WL, UK.

2. School of Biomedicine, University of Manchester & Manchester NIHR Biomedical Research Centre, Manchester, UK

3. Manchester Centre for Integrative Systems Biology, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK

4. School of Chemistry, Manchester Interdisciplinary Biocentre, University of Manchester, Manchester, UK

5. Manchester Heart Centre, Manchester Royal Infirmary, Manchester, UK

6. Manchester Academic Health Science Centre, University of Manchester, Manchester, UK

Abstract

Metabolomics is an emerging and powerful discipline that provides an accurate and dynamic picture of the phenotype of mammalian systems through the study of endogenous and exogenous metabolites in cells, tissues, culture supernatants as well as biofluids. In the last 5 years an increase in the number of metabolomic investigations of cardiovascular diseases and diabetes has been observed. In this article the experimental strategies applied and recent examples of their application in disease and drug efficacy/toxicity biomarker detection and the employment for the discovery of new molecular pathophysiological processes related to disease onset and progression, as well as their usefulness in drug efficacy/toxicity, will be reviewed. An outlook of the requirements for future successes will also be discussed.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

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