Antimicrobial, anti-TB, anticancer and anti-HIV evaluation of news-triazine-based heterocycles

Author:

Patel Rahul V1,Kumari Premlata2,Rajani Dhanji P3,Pannecouque Christophe4,De Clercq Erik4,Chikhalia Kishor H5

Affiliation:

1. Department of Applied Chemistry, S.V. National Institute of Technology, Surat 395 007, India.

2. Department of Applied Chemistry, S.V. National Institute of Technology, Surat 395 007, India

3. Microcare Laboratory, Surat 395 001, India

4. Rega Institute for Medical Research, KU Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

5. Department of Chemistry, School of Science, Gujarat University, Ahmedabad 380 009, India

Abstract

Background: The acquirement of resistance by microorganisms to the antimicrobial arsenal is a threat to public health. A recent WHO report estimated that 1.3 million HIV-negative people and 0.38 million HIV-positive people died from TB in 2009. Various forms of cancer account for a high percentage of deaths in both women (breast cancer) and men (prostate cancer). Results & discussion: In vitro activity assessment of newly constructed s-triazines against a panel of microorganisms including bacteria, fungi and Mycobacteria demonstrated that the compounds are of immense attraction for impending drug discovery. They were further examined for in vitro activity against breast cancer and prostate cancer cell lines, as well as HIV-1 (IIIB) and HIV-2 (ROD) viral strains. Proposed structural confirmation studies by IR,1H NMR,13C NMR,19F NMR spectroscopy and elemental analysis were in accordance. Conclusion: Activity profiles of the products may contribute considerably to future drug-discovery studies.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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