Dexamethasone eluting 3D printed metal devices for bone injuries-Reference-Cited by-同舟云学术

Dexamethasone eluting 3D printed metal devices for bone injuries

Published:2020-06 Issue:6 Volume:11 Page:373-386
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Poudel Ishwor¹,Annaji Manjusha¹,Arnold Robert D¹^ORCID,Kaddoumi Amal¹^ORCID,Shamsaei Nima²³^ORCID,Lee Seungjong²³,Pegues Jonathan²³,Ahmadi Zabihollah⁴,Samani Masoud M⁴³^ORCID,Corriveau Kayla⁵,Babu R Jayachandra¹^ORCID

Affiliation:

1. Department of Drug Discovery & Development, Harrison School of Pharmacy, Auburn University, Auburn, AL 36849, USA

2. Department of Mechanical Engineering, Samuel Ginn College of Engineering, Auburn University, Auburn, AL 36849, USA

3. National Center for Additive Manufacturing Excellence (NCAME), Auburn University, Auburn, AL 36849, USA

4. Department of Electrical & Computer Engineering, Samuel Ginn College of Engineering, Auburn University, Auburn, AL 36849, USA

5. Department of Clinical Sciences, College of Veterinary Medicine, Auburn University, Auburn, AL 36849, USA

Abstract

Aim: Additively manufactured (3D printed), stainless steel implants were coated with dexamethasone using gelatin, chondroitin sulfate for use in bone graft surgeries. Materials & methods: The drug and polymers were deposited on the implants with a rough surface using a high precision air brush. The gelatin-chondroitin sulfate layers were cross-linked using glutaraldehyde. Results: The drug content uniformity was within 100 ± 5%, and the thickness of the polymer layer was 410 ± 5.2 μm. The in vitro release studies showed a biphasic pattern with an initial burst release followed by slow release up to 3 days. Conclusion: These results are very promising as the slow release implants can be further tested in vivo in large animals, such as cattle and horses to prevent the inflammatory cascade following surgeries.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

https://www.future-science.com/doi/pdf/10.4155/tde-2020-0014

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