Oral fluid for the detection of drugs of abuse using immunoassay and LC

Oral fluid for the detection of drugs of abuse using immunoassay and LC–MS/MS

Published:2013-06 Issue:12 Volume:5 Page:1555-1569
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Moore Christine¹,Crouch Dennis²

Affiliation:

1. Immunalysis Corporation, Pomona, CA 91767, USA.

2. Utah Toxicology – Expert Services, LLC, Sandy, UT 84092, USA

Abstract

The utility of oral fluid as a sample matrix for the analysis of drugs has been increasing in popularity over the last few years. This is largely because of collection advantages over other matrices, but also due to the rapid improvements in analytical assays including highly sensitive liquid reagent format enzyme immunoassays and LC–MS/MS. This review will highlight improvements in assay formats, sensitivity, laboratory equipment and sample processing using low sample volumes to expand drug test profiles.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.13.115

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