Ultrasound assisted dispersive liquid–liquid microextraction followed by injector port silylation: a novel method for rapid determination of quinine in urine by GC

Ultrasound assisted dispersive liquid–liquid microextraction followed by injector port silylation: a novel method for rapid determination of quinine in urine by GC–MS

Published:2013-09 Issue:18 Volume:5 Page:2277-2286
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Jain Rajeev¹²,Mudiam Mohana Krishna Reddy³,Ch Ratnasekhar¹,Chauhan Abhishek¹,Khan Haider A²,Murthy RC¹

Affiliation:

1. Analytical Chemistry Section, CSIR-Indian Institute of Toxicology Research, M G Marg, Lucknow, 226 001, UP, India

2. Department of Medical Elementology & Toxicology, Jamia Hamdard, Hamdard Nagar, New Delhi, 110 006, India

3. Analytical Chemistry Section, CSIR-Indian Institute of Toxicology Research, M G Marg, Lucknow, 226 001, UP, India.

Abstract

Background: Silylation is a widely used derivatization method for the analysis of polar analytes by GC–MS. Ultrasound-assisted dispersive liquid–liquid microextraction (UA-DLLME) is an ecofriendly, rapid and simple microextraction method. For the first time, a novel approach has been developed and applied for the analysis of quinine in urine by combining UA-DLLME with injection port silylation. Results: The LOD and LOQ were found to be 5.4 and 18 ng/ml. The intra- and inter-day precisions were less than 5 and 8%, respectively. Mean recoveries of quinine were found to be in the range of 87 to 96%. Conclusion: Ultrasound-assisted dispersive liquid–liquid microextraction is rapid, simple and consumes less reagent for the analysis of polar analytes such as quinine.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.13.188

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