Small-molecule MDM2-p53 inhibitors: recent advances-Reference-Cited by-同舟云学术

Small-molecule MDM2-p53 inhibitors: recent advances

Published:2015-04 Issue:5 Volume:7 Page:631-645
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Zhang Bian¹,Golding Bernard T¹,Hardcastle Ian R¹

Affiliation:

1. Newcastle Cancer Centre, School of Chemistry, Bedson Building, Newcastle University, NE1 7RU, UK

Abstract

Potent and selective small-molecule inhibitors of the p53-MDM2 interaction intended for the treatment of p53 wild-type tumors have been designed and optimized in a number of chemical series. This review details recent disclosures of compounds in advanced optimization and features key series that have given rise to clinical trial candidates. The structure–activity relationships for inhibitor classes are discussed with reference to x-ray structures, and common structural features are identified.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.15.13

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