ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease-Reference-Cited by-同舟云学术

ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease

Published:2015-12 Issue:18 Volume:7 Page:2451-2467
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Shibuya Yohei¹,Chang Catherine CY¹,Chang Ta-Yuan¹

Affiliation:

1. Department of Biochemistry, Geisel School of Medicine at Dartmouth, 304 Vail Building, Hanover, NH 03755, USA

Abstract

Alzheimer's disease (AD) is the most common cause of dementia with no cure at present. Cholesterol metabolism is closely associated with AD at several stages. ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis. Recent studies show that in a mouse model, blocking ACAT1 provides multiple beneficial effects on AD. Here we review the current evidence that implicates ACAT1 as a therapeutic target for AD. We also discuss the potential usage of various ACAT inhibitors currently available to treat AD.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.15.161

Reference131 articles.

1. Consequences of cellular cholesterol accumulation: basic concepts and physiological implications

2. Cholesterol Sensing, Trafficking, and Esterification

3. Acyl-coenzyme A:cholesterol acyltransferases

4. Alzheimer’s disease: the lipid connection

5. Linking lipids to Alzheimer's disease: cholesterol and beyond

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