ACAT1/SOAT1 as a therapeutic target for Alzheimer's disease

Author:

Shibuya Yohei1,Chang Catherine CY1,Chang Ta-Yuan1

Affiliation:

1. Department of Biochemistry, Geisel School of Medicine at Dartmouth, 304 Vail Building, Hanover, NH 03755, USA

Abstract

Alzheimer's disease (AD) is the most common cause of dementia with no cure at present. Cholesterol metabolism is closely associated with AD at several stages. ACAT1 converts free cholesterol to cholesteryl esters, and plays important roles in cellular cholesterol homeostasis. Recent studies show that in a mouse model, blocking ACAT1 provides multiple beneficial effects on AD. Here we review the current evidence that implicates ACAT1 as a therapeutic target for AD. We also discuss the potential usage of various ACAT inhibitors currently available to treat AD.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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