Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC

Detection and quantification of 56 new psychoactive substances in whole blood and urine by LC–MS/MS

Published:2015-05 Issue:9 Volume:7 Page:1119-1136
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Ambach Lars¹,Hernández Redondo Ana¹,König Stefan¹,Angerer Verena²,Schürch Stefan³,Weinmann Wolfgang¹

Affiliation:

1. Institute of Forensic Medicine, University of Bern, Bern, Switzerland

2. Institute of Forensic Medicine, Medical Center, University of Freiburg, Freiburg, Germany

3. Department of Chemistry & Biochemistry, University of Bern, Bern, Switzerland

Abstract

Background: New psychoactive substances (NPS) have become increasingly prevalent and are sold in internet shops as ‘bath salts’ or ‘research chemicals’ and comprehensive bioanalytical methods are needed for their detection. Methodology: We developed and validated a method using LC and MS/MS to quantify 56 NPS in blood and urine, including amphetamine derivatives, 2C compounds, aminoindanes, cathinones, piperazines, tryptamines, dissociatives and others. Instrumentation included a Synergi Polar-RP column (Phenomenex) and a 3200 QTrap mass spectrometer (AB Sciex). Run time was 20 min. Conclusion: A novel method is presented for the unambiguous identification and quantification of 56 NPS in blood and urine samples in clinical and forensic cases, e.g., intoxications or driving under the influence of drugs.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.15.48

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