Direct quantitation of therapeutic antibodies for pharmacokinetic studies using immuno-purification and intact mass analysis
Author:
Affiliation:
1. Pharmacokinetics, Pharmacodynamics & Drug Metabolism, Merck & Co., Inc., 770 Sumneytown Pike, West Point, PA 19486, USA
2. Agilent Technologies, 2850 Centerville Rd, Wilmington, DE 19808, USA
Abstract
Publisher
Future Science Ltd
Subject
Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry
Link
https://www.future-science.com/doi/pdf/10.4155/bio-2018-0240
Reference38 articles.
1. Strategy for the Quantitation of a Protein Conjugate via Hybrid Immunocapture-Liquid Chromatography with Sequential HRMS and SRM-Based LC-MS/MS Analyses
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4. Bioanalytical LC–MS/MS of protein-based biopharmaceuticals
5. Generic Automated Method for Liquid Chromatography–Multiple Reaction Monitoring Mass Spectrometry Based Monoclonal Antibody Quantitation for Preclinical Pharmacokinetic Studies
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1. Monitoring mAb proteoforms in mouse plasma using an automated immunocapture combined with top‐down and middle‐down mass spectrometry;PROTEOMICS;2023-07-21
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