Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010-Reference-Cited by-同舟云学术

Inhibitors of voltage-gated sodium channel Nav1.7: patent applications since 2010

Published:2014-09 Issue:5 Volume:3 Page:509-521
ISSN:2046-8954
Container-title:Pharmaceutical Patent Analyst
language:en
Short-container-title:Pharmaceutical Patent Analyst

Author:

Sun Shaoyi¹,J Cohen Charles¹,M Dehnhardt Christoph¹

Affiliation:

1. Xenon Pharmaceuticals Inc., 200–3650 Gilmore Way, Burnaby, BC, V5G 4W8, Canada

Abstract

There has been intense interest in developing inhibitors of the sodium channel Nav1.7 because genetic studies have established very strong validation for the efficacy to alleviate both inflammatory and neuropathic pain. This review summarizes patent applications targeting Nav1.7 since 2010 until May, 2014. We have classified the patents into three categories as follows: small molecules with well-defined molecular selectivity among sodium channel isoforms; biologicals with well-defined molecular selectivity; and, small molecules that inhibit Nav1.7 with unknown molecular selectivity. Most of the review is dedicated to small molecule selective compounds.

Publisher

Future Science Ltd

Subject

General Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/ppa.14.39

Reference110 articles.

1. An SCN9A channelopathy causes congenital inability to experience pain

2. Loss-of-function mutations in the Nav1.7 gene underlie congenital indifference to pain in multiple human populations

3. Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons

4. SCN9A Mutations in Paroxysmal Extreme Pain Disorder: Allelic Variants Underlie Distinct Channel Defects and Phenotypes

5. Mouse Model of SCN5A -Linked Hereditary Lenègre’s Disease

Cited by 31 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. NaV1.7 channels are expressed in the lower airways of the human respiratory tract;Respiratory Physiology & Neurobiology;2023-05

2. Novel Therapies for the Treatment of Neuropathic Pain: Potential and Pitfalls;Journal of Clinical Medicine;2022-05-26

3. Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel;Journal of Ethnopharmacology;2021-12

4. The mechanism of non‐blocking inhibition of sodium channels revealed by conformation‐selective photolabeling;British Journal of Pharmacology;2021-02

5. Fifteen years of Na V 1.7 channels as an analgesic target: Why has excellent in vitro pharmacology not translated into in vivo analgesic efficacy?;British Journal of Pharmacology;2020-12-18