Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts-Reference-Cited by-同舟云学术

Super-conserved receptors expressed in the brain: biology and medicinal chemistry efforts

Published:2022-06 Issue:12 Volume:14 Page:899-913
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Bayrak Alp¹^ORCID,Hanson Julien²³^ORCID,Laufer Stefan¹^ORCID,Pillaiyar Thanigaimalai¹^ORCID

Affiliation:

1. Institute of Pharmacy, Pharmaceutical/Medicinal Chemistry & Tübingen Center for Academic Drug Discovery (TüCAD2) Eberhard Karls University Tübingen, Auf der Morgenstelle 8, 72076 Tübingen, Germany

2. Laboratory of Molecular Pharmacology, GIGA-Molecular Biology of Diseases, University of Liège, B-4000 Liège, Belgium

3. Laboratory of Medicinal Chemistry, Centre for Interdisciplinary Research on Medicines (CIRM), University of Liège, B-4000 Liège, Belgium

Abstract

The super-conserved receptors expressed in the brain (SREB) constitute a family of orphan G protein-coupled receptors that include GPR27 (SREB1), GPR85 (SREB2) and GPR173 (SREB3). Their sequences are highly conserved in vertebrates, and they are almost exclusively expressed in the central nervous system. This family of receptors has attracted much attention due to their putative physiological functions and their potential as novel drug targets. The SREB family has been postulated to play important roles in a wide range of different diseases, including pancreatic β-cell insulin secretion and regulation, schizophrenia, autism and atherosclerosis. This review intends to provide a comprehensive overview of the SREB family and its recent advances in biology and medicinal chemistry.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2022-0006

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