Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies-Reference-Cited by-同舟云学术

Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies

Published:2023-03 Issue:5 Volume:15 Page:421-436
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Shehta Wael¹^ORCID,Agili Fatimah²,Farag Basant¹,Said Said A¹,Youssif Shaker¹^ORCID,Abdraboh Mohamed E³,El-Kalyoubi Samar⁴^ORCID

Affiliation:

1. Department of Chemistry, Faculty of Science, Zagazig University, Zagazig, 44519, Egypt

2. Department of Chemistry, Faculty of Science (Female Section), Jazan University, Jazan, 82621, Saudi Arabia

3. Department of Zoology, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt

4. Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Port Said University, Port Said, 42511, Egypt

Abstract

Aim: Synthesis of novel pyran-based uracils that may have potent antitumor activity against hepatocellular carcinoma HepG2 and ovarian cancer SKOV3 cell lines. Materials & methods: Novel pyran-based uracils were synthesized and their anticancer activity was assessed using methyl thiazolyl tetrazolium and wound-healing assays to detect their cytotoxicity and their antiproliferative and antimigratory activities. Results: Compounds 3, 5, 6, 7, 8, 9, 10, 11 and 13 significantly inhibited cell proliferation of the HepG2 cell line. Compounds 7, 8, 9 and 13 significantly inhibited the proliferation of SKOV3 cells, which was also proven through docking studies with topoisomerase I. Conclusion: The molecular docking analysis revealed that 7 and 9 are two major compounds found to possess higher degrees of interaction with DNA gyrase.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2022-0279

Reference41 articles.

1. Application of dimedone enamines as dienophiles: stereoselective synthesis of amino enols of fused uracils containing a sugar moiety by hetero-Diels–Alder reactions of barbituric acid 5-ylidene alditols with dimedone enamines

2. Synthesis of fused uracils: pyrano[2,3-d]pyrimidines and 1,4-bis(pyrano[2,3-d]pyrimidinyl)benzenes by domino Knoevenagel/Diels-Alder reactions

3. Synthesis of pyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidin-5-ones as potential antimicrobial agents

4. Synthesis of Pyrazolo[4′,3′:5,6]pyrano[2,3-d]pyrimidine Derivatives for Antiviral Evaluation

5. Development of 2-aryl substituted quinazolin-4(3H)-one, pyrido[4,3-d]pyrimidin-4(3H)-one and pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as microsomal prostaglandin E2 synthase-1 inhibitors

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Novel Hydrazide Hydrazone Derivatives as Antimicrobial Agents: Design, Synthesis, and Molecular Dynamics;Processes;2024-05-22

2. Novel Thiazole Derivatives Containing Imidazole and Furan Scaffold: Design, Synthesis, Molecular Docking, Antibacterial, and Antioxidant Evaluation;Molecules;2024-03-27

3. Uracil: A Pharmacophore with Diverse Biological Potential;ChemistrySelect;2024-01-29