Bioanalytical techniques for detecting biomarkers of response to human asbestos exposure

Author:

Mesaros Clementina123,Worth Andrew J123,Snyder Nathaniel W24,Christofidou-Solomidou Melpo125,Vachani Anil125,Albelda Steven M125,Blair Ian A123

Affiliation:

1. Penn SRP Center, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA

2. Center of Excellence in Environmental Toxicology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA

3. Department of Systems Pharmacology & Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA

4. Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6160, USA

5. A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA 19104, USA

Abstract

Asbestos exposure is known to cause lung cancer and mesothelioma and its health and economic impacts have been well documented. The exceptionally long latency periods of most asbestos-related diseases have hampered preventative and precautionary steps thus far. We aimed to summarize the state of knowledge on biomarkers of response to asbestos exposure. Asbestos is not present in human biological fluids; rather it is inhaled and trapped in lung tissue. Biomarkers of response, which reflect a change in biologic function in response to asbestos exposure, are analyzed. Several classes of molecules have been studied and evaluated for their potential utility as biomarkers of asbestos exposure. These studies range from small molecule oxidative stress biomarkers to proteins involved in immune responses.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

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