Medicinal chemistry of ρ GABAC receptors-Reference-Cited by-同舟云学术

Medicinal chemistry of ρ GABAC receptors

Published:2011-02 Issue:2 Volume:3 Page:197-209
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Ng Clarissa KL¹,Kim Hye-lim¹,Gavande Navnath¹,Yamamoto Izumi¹,Kumar Rohan J¹,Mewett Kenneth N²,Johnston Graham AR²,Hanrahan Jane R¹,Chebib Mary

Affiliation:

1. Faculty of Pharmacy A15, The University of Sydney, NSW, Australia 2006

2. Adrien Albert Laboratory of Medicinal Chemistry, Department of Pharmacology D06, The University of Sydney, NSW, Australia 2006

Abstract

The inhibitory neurotransmitter, GABA, is a low-molecular-weight molecule that can achieve many low-energy conformations, which are recognized by GABA receptors and transporters. In this article, we assess the structure–activity relationship profiles of GABA analogs at the ionotropic ρ GABAC receptor. Such studies have significantly contributed to the design and development of potent and selective agonists and antagonists for this subclass of GABA receptors. With these tools in hand, the role of ρ GABAC receptors is slowly being realized. Of particular interest is the development of selective phosphinic acid analogs of GABA and their potential use in sleep disorders, inhibiting the development of myopia, and in improving learning and memory.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc.10.286

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