Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation-Reference-Cited by-同舟云学术

Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: a PCR validation

Published:2021-03 Issue:6 Volume:13 Page:543-549
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Mehta Meenu¹²^ORCID,Paudel Keshav Raj²³^ORCID,Shukla Shakti D⁴^ORCID,Shastri Madhur D⁵^ORCID,Satija Saurabh⁶^ORCID,Singh Sachin Kumar⁶^ORCID,Gulati Monica⁶^ORCID,Dureja Harish⁷^ORCID,Zacconi Flavia C⁸^ORCID,Hansbro Philip M²³^ORCID,Chellappan Dinesh Kumar⁹^ORCID,Dua Kamal¹²⁴¹⁰^ORCID

Affiliation:

1. Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, NSW 2007, Australia

2. Centre for Inflammation, Centenary Institute, Sydney, NSW 2050, Australia

3. School of Life Sciences, Faculty of Science, University of Technology Sydney, NSW 2007, Australia

4. Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute (HMRI), University of Newcastle, New Lambton Heights, Newcastle, NSW 2305, Australia

5. School of Health Sciences, College of Health & Medicine, University of Tasmania, Launceston, TAS 7250, Australia

6. School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab 144411, India

7. Department of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak, Haryana 124001, India

8. Departamento de Química Orgánica, Facultad de Química y de Farma-cia, Pontificia Universidad Católica deChile, Av. Vicuña Mackenna 4860, Macul, Santiago 7820436, Chile

9. Department of Life Sciences, School of Pharmacy, International Medical University (IMU), Bukit Jalil 57000, Kuala Lumpur, Malaysia

10. School of Pharmaceutical Sciences, Shoolini University, Solan, Himachal Pradesh 173229, India

Abstract

Aim: In the present study, the inhibitory potential of rutin-loaded liquid crystalline nanoparticles (LCNs) on oxidative stress was determined in human bronchial epithelial cells (BEAS-2B) by analysing the expression levels of different antioxidant (NADPH quinine oxidoreductase-1 ( NQO1); γ-glutamyl cysteine synthetase catalytic subunit ( GCLC)) and pro-oxidant (NADPH oxidase (Nox)-4; Nox2B) genes. Results: Our findings revealed that the rutin-loaded LCNs inhibited the genes, namely Nox2B and Nox4, which caused oxidative stress. In addition, these nanoparticles demonstrated an upregulation in the expression of the antioxidant genes Gclc and Nqo-1 in a dose-dependent manner. Conclusion: The study indicates the promising potential of rutin-loaded LCNs as an effective treatment strategy in patients with high oxidant loads in various respiratory diseases.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2020-0297

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