Neurotensins and their therapeutic potential: research field study

Author:

Kan Yeung Andy Wai1ORCID,Georgieva Maya G2,Kirilov Kiril2,Balacheva Aneliya A2,Peeva Martina I2,Horbańczuk Olaf K3,Horbańczuk Jarosław O4,Lucarini Massimo5ORCID,Durazzo Alessandra5ORCID,Santini Antonello6,Souto Eliana B78,Pajpanova Tamara I2,Milella Luigi910ORCID,Atanasov Atanas G4111213ORCID,Tzvetkov Nikolay T2ORCID

Affiliation:

1. Oral & Maxillofacial Radiology, Applied Oral Sciences & Community Dental Care, Faculty of Dentistry, The University of Hong Kong, Hong Kong, China

2. Institute of Molecular Biology “Roumen Tsanev”, Department of Biochemical Pharmacology & Drug Design, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113 Sofia, Bulgaria

3. Division of Engineering in Nutrition, Department of Technique & Food Product Development, Warsaw University of Life Sciences (WULS-SGGW) 159c Nowoursynowska, 02-776 Warsaw, Poland

4. The Institute of Genetics & Animal Biotechnology, Polish Academy of Sciences, Jastrzębiec, 05-552 Magdalenka, Poland

5. CREA-Research Centre for Food & Nutrition, Via Ardeatina 546, 00178, Rome, Italy

6. Department of Pharmacy, University of Napoli Federico II, Via D. Montesano 49, 80131, Napoli, Italy

7. Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Coimbra, Polo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548, Coimbra, Portugal

8. CEB – Centre of Biological Engineering, University of Minho, Campus de Gualtar 4710-057, Braga, Portugal

9. Department of Science, Universitá degli Studi della Basilicata, V.le Ateneo Lucano 10, 85100, Potenza, Italy

10. Spinoff BioActiPlant S.R.L. Department of Science, University of Basilicata, V.le dell'Ateneo lucano, 10, 85100, Potenza, Italy

11. Department of Pharmacognosy, University of Vienna, Vienna, Austria

12. Institute of Neurobiology, Bulgarian Academy of Sciences, Sofia, Bulgaria

13. Ludwig Boltzmann Institute for Digital Health & Patient Safety, Medical University of Vienna, Spitalgasse 23, 1090, Vienna, Austria

Abstract

The natural tridecapeptide neurotensin has been emerged as a promising therapeutic scaffold for the treatment of neurological diseases and cancer. In this work, we aimed to identify the top 100 most cited original research papers as well as recent key studies related to neurotensins. The Web of Science Core Collection database was searched and the retrieved research articles were analyzed by using the VOSviewer software. The most cited original articles were published between 1973 and 2013. The top-cited article was by Carraway and Leeman reporting the discovery of neurotensin in 1973. The highly cited terms were associated with hypotension and angiotensin-converting-enzyme. The conducted analysis reveals the therapeutic potentials of neurotensin, and further impactful research toward its clinical development is warrantied.

Funder

Bulgarian National Science Found

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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