Virtual screening and assessment of anticancer potential of selenium-based compounds against HL-60 and MCF7 cells-Reference-Cited by-同舟云学术

Virtual screening and assessment of anticancer potential of selenium-based compounds against HL-60 and MCF7 cells

Published:2020-12 Issue:24 Volume:12 Page:2191-2207
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Ferreira de Queiroz Ericka Fernanda¹,de Sousa Luis José Alixandre²,de Sousa Dantas Diego³,Pereira Arruda Lúcia Cristina⁴,Cordeiro Bento da Silva Ellen¹,de Sousa e Silva João Manoel²,da Silva Souza Helivaldo Diogenes⁵^ORCID,Costa Barros Renata Priscila⁶,de Mascena Costa Luciana Amaral¹,de Athayde Filho Petrônio Figueiras⁵,Scotti Luciana⁶^ORCID,Scotti Marcus Tullius⁶^ORCID,Gomes Filho Manoel Adrião¹

Affiliation:

1. Department of Animal Morphology & Physiology, Federal Rural University of Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Zip code: 52171900, Recife – Pernambuco, Brazil

2. Education & Health Center, Federal University of Campina Grande, Cuité – Paraíba 58175000, Brazil

3. Federal University of Pernambuco, Av. Prof. Moraes Rego, 1235 – Cidade Universitária, Recife – Pernambuco 50670901, Brazil

4. Department of Veterinary, Federal Rural University of Pernambuco, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife – Pernambuco 52171900, Brazil

5. Research Laboratory in Biofuels & Organic Synthesis, Department of Chemistry, Federal University of Paraíba, Campus I – Lot. Cidade Universitaria, João Pessoa – Paraíba 58051900, Brazil

6. Postgraduate Program in Natural & Synthetic Bioactive Products, Federal University of Paraíba, Campus I – Lot. Cidade Universitaria, João Pessoa – Paraíba 58051900, Brazil

Abstract

Aim: Selenium-based compounds have antitumor potential. We used a ligand-based virtual screening analysis to identify selenoglycolicamides with potential antitumor activity. Results & Conclusion: Compounds 3, 6, 7 and 8 were selected for in vitro cytotoxicity tests against various cell lines, according to spectrophotometry results. Compound 3 presented the best cytotoxicity results against a promyelocytic leukemia line (HL-60) and was able to induce cell death at a frequency similar to that observed for doxorubicin. The docking study showed that compound 3 has good interaction energies with the targets caspase-3, 7 and 8, which are components of the apoptotic pathway. These results suggested that selenium has significant pharmacological potential for the selective targeting of tumor cells, inducing molecular and cellular events that culminate in tumor cell death.

Funder

Fundação de Amparo à Ciência e Tecnologia do Estado de Pernambuco

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2020-0110

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