Key bioanalytical measurements for antibody–drug conjugate development: PK/PD modelers’ perspective-Reference-Cited by-同舟云学术

Key bioanalytical measurements for antibody–drug conjugate development: PK/PD modelers’ perspective

Published:2013-05 Issue:9 Volume:5 Page:989-992
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Shah Dhaval K¹,Barletta Frank²,Betts Alison²,Hansel Steven²

Affiliation:

1. Translational Research Group, Department of Pharmacokinetics Dynamics & Metabolism, Pfizer World Wide Research & Development, Eastern Point Road, Groton, CT 06340, USA.

2. Department of Pharmacokinetics, Dynamics & Metabolism, Pfizer World Wide Research & Development, CT, USA

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.13.78

Reference19 articles.

1. Bench to bedside translation of antibody drug conjugates using a multiscale mechanistic PK/PD model: a case study with brentuximab-vedotin

2. Computational modeling of the EGF-receptor system: a paradigm for systems biology

3. Intracellular Activation of SGN-35, a Potent Anti-CD30 Antibody-Drug Conjugate

4. Physiologically based pharmacokinetic model for topotecan in mice

5. Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

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