Advances in urinary proteome analysis and applications in systems biology

Author:

Filip Szymon12,Zoidakis Jerome1,Vlahou Antonia1,Mischak Harald34

Affiliation:

1. Biotechnology Division, Biomedical Research Foundation Academy of Athens, Athens, Greece

2. Charité – Universitätsmedizin Berlin, Berlin, Germany

3. Mosaiques Diagnostics GmbH, Hannover, Germany

4. Institute of Cardiovascular and Medical Sciences University of Glasgow, Glasgow, UK

Abstract

The urinary proteome is the focus of many studies due to the ease of urine collection and the relative proteome stability. Systems biology allows the combination of multiple omics studies, forming a link between proteomics, metabolomics, genomics and transcriptomics. In-depth data interpretation is achieved by bioinformatics analysis of -omics data sets. It is expected that the contribution of systems biology to the study of the urinary proteome will offer novel insights. The main focus of this review is on technical aspects of proteomics studies, available tools for systems biology analysis and the application of urinary proteomics in clinical studies and systems biology.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

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