Reducing pre-clinical blood volumes for toxicokinetics: toxicologists, pathologists and bioanalysts unite

Author:

Chapman Kathryn1,Burnett Josephine2,Corvaro Marco3,Mitchell David4,Robinson Sally5,Sangster Timothy6,Sparrow Susan7,Spooner Neil7,Wilson Amanda5

Affiliation:

1. National Centre for the Replacement, Refinement & Reduction of Animals in Research (NC3Rs), London, UK

2. Covance Laboratories, Harrogate, UK

3. Dow AgroSciences, UK

4. Huntingdon Life Sciences, Huntingdon, UK

5. Astra Zeneca, Macclesfield, UK

6. Charles River Laboratories, Edinburgh, UK

7. Glaxo Smith Kline, Ware, UK

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Reference21 articles.

1. Test No. 426: Developmental Neurotoxicity Study

2. Test No. 417: Toxicokinetics

3. OECD. Guidance document 116 on the conduct and design of chronic toxicity and carcinogenicity studies supporting test guidelines 451, 452 and 453. 2nd Edition. OECD Publishing, Paris, France, 47 (2012).

4. OECD. Series on testing and assessment no. 151. Guidance document supporting OECD test guideline 443 on the extended one generation reproductiove toxicity study. (ENV/JM/MONO10. OECD, Paris, France (2013).

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