Application of iron oxide nanoparticles to control the release of minocycline for the treatment of glioblastoma

Author:

Arriaga Marco A1ORCID,Enriquez Dean Michael1,Salinas Arely D1,Garcia Jr. Romeo1,Trevino De Leo Carlos2,Lopez Silverio A2,Martirosyan Karen S2,Chew Sue Anne1

Affiliation:

1. Department of Health & Biomedical Sciences, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA

2. Department of Physics & Astronomy, University of Texas Rio Grande Valley, Brownsville, TX 78520, USA

Abstract

Background: The utilization of iron oxide nanoparticles (Fe3O4 NPs) to control minocycline release rates from poly(lactic-co-glycolic acid) scaffolds fabricated from an easy/economical technique is presented. Results & methodology: A larger change in temperature and amount of minocycline released was observed for scaffolds with higher amounts of Fe3O4 NPs, demonstrating that nanoparticle concentration can control heat generation and minocycline release. Temperatures near a polymer’s glass transition temperature can result in the polymer’s chain becoming more mobile and thus increasing drug diffusion out of the scaffold. Elevated temperature and minocycline released from the scaffold can work synergistically to enhance glioblastoma cell death. Conclusion: This study suggests that Fe3O4 NPs are promising materials for controlling minocycline release from polymeric scaffolds by magnetic hyperthermia for the treatment of glioblastoma.

Funder

National Science Foundation PREM

National Institutes of Health

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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