Quantitative chromatographic method development for residual lidocaine in topical systems and biological samples-Reference-Cited by-同舟云学术

Quantitative chromatographic method development for residual lidocaine in topical systems and biological samples

Published:2023-05 Issue:10 Volume:15 Page:553-566
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Bhatt Jayshil A¹²³^ORCID,Wei Hui¹³^ORCID,Azarpanah Armita¹³^ORCID,Morris Kenneth R¹^ORCID,Cai Qing¹³⁴^ORCID

Affiliation:

1. Lachman Institute for Pharmaceutical Analysis, Long Island University, Brooklyn, NY, USA

2. Synthetic Enabling Technologies, Product & Process Development, Drug Product Technologies, Amgen, Inc., One Amgen Center Drive, Thousand Oaks, CA 91320, USA

3. Division of Pharmaceutical Sciences, Arnold & Marie Schwartz College of Pharmacy & Health Sciences, Long Island University, Brooklyn, NY, USA

4. Analytical Characterization, R&D, Ethicon Inc, Johnson & Johnson, Raritan, NJ 08869, USA

Abstract

Background: The aim of this work was to develop and validate sensitive and efficient analytical methods for estimating systemic drug exposure and residual drug following the application of topical delivery systems. Materials & methods: Lidocaine was extracted using a liquid–liquid extraction technique from commercial topical products and analyzed using ultra high-performance liquid chromatography. A separate LC–MS/MS method was developed for analyzing human serum samples. Results & conclusion: The developed methods were successfully applied for estimating lidocaine content in two commercial products demonstrating 97.4–104.0% for product A and 105.0–110.7% for product B. The LC–MS/MS method displayed successful analysis of lidocaine from human serum samples. The developed methods are recommended for quantifying systemic exposure and residual drug analysis of topical systems.

Funder

U.S. Food and Drug Administration

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

https://www.future-science.com/doi/pdf/10.4155/bio-2023-0034

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