A new approach with dried plasma spots: a rapid determination of antidepressants and antipsychotics by fast GC–MS

Author:

de Gouveia Giovanna Cristiano1ORCID,dos Santos Bruno Pereira12ORCID,Borges Gabriela Ramos1ORCID,Sebben Viviane Cristina3ORCID,Eller Sarah1ORCID,de Oliveira Tiago Franco1ORCID

Affiliation:

1. Graduate Program in Health Sciences, Federal University of Health Sciences of Porto Alegre, Porto Alegre, RS, 90050-170, Brazil

2. Faculty of Pharmacy, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90010-150, Brazil

3. Toxicological Information Center of Rio Grande do Sul, Porto Alegre, RS, 90610-000, Brazil

Abstract

Background: The increasing prevalence of poisoning cases related to antidepressants and antipsychotics has raised concerns. Methods: To address this issue, a new adaptation of the dried plasma spot technique was developed using a 24-well plate and fast gas chromatography-mass spectrometry. The method involves the optimization of extraction variables and sample preparation, and was successfully validated. Results: The limits of quantitation ranged from 20 to 60 ng/ml, and accuracy ranged from 87.8% to 112.2%. The technique was applied to 102 human plasma samples from suspected poisoning cases, with positivity of 90.2%. Conclusion: This method provides a cheap, easy to implement and fast approach, making it ideal for toxicological emergency laboratories and promoting valuable support for healthcare professionals managing poisoning cases involving antidepressants and antipsychotics.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

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