Dried blood spots, pharmacokinetic studies and better medicines for children-Reference-Cited by-同舟云学术

Dried blood spots, pharmacokinetic studies and better medicines for children

Published:2011-04 Issue:7 Volume:3 Page:779-786
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Pandya Hitesh C¹,Spooner Neil²,Mulla Hussain³

Affiliation:

1. Department of Infection, Immunity & Inflammation, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Infirmary Square, PO BOX 65, Leicester LE2 7LX, UK.

2. Platform Technologies & Science, Drug Metabolism & Pharmacokinetics, GlaxoSmithKline Research & Development, Ware, UK

3. Centre for Therapeutic Evaluation of Drugs in Children, University Hospitals NHS Trust Leicester, Glenfield, Leicester, UK

Abstract

Determining circulating drug concentrations in children is an ongoing obstacle to the development of age-appropriate dosing regimens. The requirement for small blood sample volumes in children compared with adults is a significant barrier to obtaining age-specific pharmacokinetic–pharmacodynamic data for this population and hence optimizing the efficacy and safety profile of medicines used by this group. This article discusses the potential for dried blood spot sampling to offer a solution to this issue.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.11.19

Reference53 articles.

1. Evaluating newborn screening programmes based on dried blood spots: future challenges

2. On-line desorption of dried blood spot: A novel approach for the direct LC/MS analysis of μ-whole blood samples

3. Dried Blood Spots as a Sample Collection Technique for the Determination of Pharmacokinetics in Clinical Studies: Considerations for the Validation of a Quantitative Bioanalytical Method

4. Study of dried blood spots technique for the determination of dextromethorphan and its metabolite dextrorphan in human whole blood by LC–MS/MS

5. Serum, plasma, and dried blood spot high-sensitivity C-reactive protein enzyme immunoassay for population research

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