Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast-Reference-Cited by-同舟云学术

Combining hard and soft magnetism into a single core-shell nanoparticle to achieve both hyperthermia and image contrast

Published:2015-10 Issue:10 Volume:6 Page:1195-1210
ISSN:2041-5990
Container-title:Therapeutic Delivery
language:en
Short-container-title:Therapeutic Delivery

Author:

Yang Qiuhong¹,Gong Maogang²,Cai Shuang¹,Zhang Ti¹,Douglas Justin T³,Chikan Viktor⁴,Davies Neal M⁵,Lee Phil⁶⁷,Choi In-Young⁶⁸,Ren Shenqiang⁹,Forrest M Laird¹

Affiliation:

1. Department of Pharmaceutical Chemistry, University of Kansas, Lawrence, KS 66047, USA

2. Department of Chemistry, University of Kansas, Lawrence, KS 66045, USA

3. Nuclear Magnetic Resonance Laboratory, University of Kansas, Lawrence, KS 66045, USA

4. Department of Chemistry, Kansas State University, Manhattan, KS 66506, USA

5. The Faculty of Pharmacy, University of Manitoba, Winnipeg, MB R3E OT5, Canada

6. Hoglund Brain Imaging Center, University of Kansas Medical Center, Kansas City, KS 66160, USA

7. Department of Molecular & Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA

8. Department of Neurology, University of Kansas Medical Center, Kansas City, KS 66160, USA

9. Department of Mechanical Engineering and Temple Material Institute, Temple University, Philadelphia, PA 19122, USA

Abstract

Background: A biocompatible core/shell structured magnetic nanoparticles (MNPs) was developed to mediate simultaneous cancer therapy and imaging. Methods & results: A 22-nm MNP was first synthesized via magnetically coupling hard (FePt) and soft (Fe3O4) materials to produce high relative energy transfer. Colloidal stability of the FePt@Fe3O4 MNPs was achieved through surface modification with silane-polyethylene glycol (PEG). Intravenous administration of PEG-MNPs into tumor-bearing mice resulted in a sustained particle accumulation in the tumor region, and the tumor burden of treated mice was a third that of the mice in control groups 2 weeks after a local hyperthermia treatment. In vivo magnetic resonance imaging exhibited enhanced T2 contrast in the tumor region. Conclusion: This work has demonstrated the feasibility of cancer theranostics with PEG-MNPs.

Publisher

Future Science Ltd

Subject

Pharmaceutical Science

Link

http://www.future-science.com/doi/pdf/10.4155/tde.15.68

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