Synthesis, structural and antimicrobial studies of binary and ternary complexes of a new tridentate thiosemicarbazone

Author:

M Ibrahim Ahmed B1,Farh Micheal K1,Plaisier Jasper R2,Shalaby ElSayed M23

Affiliation:

1. Department of Chemistry, Faculty of Science, Assiut University, Assiut 71515, Egypt

2. Elettra-Sincrotrone Trieste S.C.p.A., AREA Science Park, 34149 Basovizza, Trieste, Italy

3. X-Ray Crystallography Lab., Physics Division, National Research Centre, Dokki, Giza 12622, Egypt

Abstract

A new thiosemicarbazone ligand was synthesized and characterized using spectroscopic techniques (UV-Vis and IR) and synchrotron x-ray powder diffraction. With M2+ = Mn2+, Zn2+ and Cd2+, coordination compounds of the type (M[L]2) were isolated. In the presence of sodium dithiocarbamate salts (NadiEtdtc.3H2O = sodium diethyldithiocarbamate trihydrate and Napipdtc = sodium piperidinedithiocarbamate), Zn2+ and Cd2+ were able to form ternary octahedral complexes where each metal binds a deprotonated (thiosemicarbazone) ligand, a monobasic dithiocarbamate ligand and a water molecule. In vitro biological evaluation tests of the free HL ligand and its metal complexes against selected fungal and bacterial cultures were performed. Compared with HL, the complexes displayed enhanced biological activities and ternary Zn (II) complexes displayed comparable antibacterial activities to the chloramphenicol standard.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

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