Synthesis, characterization and antidiabetic effects of vanadyl(II) adenosine monophosphate amino acid mixed-ligand complexes-Reference-Cited by-同舟云学术

Synthesis, characterization and antidiabetic effects of vanadyl(II) adenosine monophosphate amino acid mixed-ligand complexes

Published:2019-02 Issue:3 Volume:11 Page:193-210
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Naglah Ahmed M¹²,Al-Omar Mohamed A¹,Kalmouch Atef²,Alsuhaibani Amnah MA³,El-Didamony Akram M⁴,Hassan Nader⁵,Taleb Sameh Abo⁵,Refat Moamen S⁵⁶,Almehizia Abdulrahman A⁷,Bhat Mashooq A⁷,Al-Shakliah Nasser S⁷,Al-Humaidi Jehan Y⁸,Al-Wasidi Asma S⁸

Affiliation:

1. Department of Pharmaceutical Chemistry, Drug Exploration & Development Chair (DEDC), College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

2. Peptide Chemistry Department, Chemical Industries Research Division, National Research Centre, 12622-Dokki, Cairo, Egypt

3. Nutrition & Food Sciences Department, Home Economic College, Princess Nourah Bint Abdulrahman University, Riyadh 11671, Saudi Arabia

4. Department of Chemistry, Faculty of Science, Zagazig University, Egypt

5. Department of Chemistry, Faculty of Science, Port Said, Port Said University, Egypt

6. Chemistry Department, Faculty of Science, Taif University, PO Box 888, Al-Hawiah, Taif 21974, Saudi Arabia

7. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh 11451, Saudi Arabia

8. Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671, Saudi Arabia

Abstract

Aim: This research paper is aimed at designing a novel insulin alternative for the treatment of diabetes. Materials & methods: Six novel vanadyl(II) compounds, [(AMP−2)(VO+2)(AA n −1)]·NH4 +1, were synthesized from an equimolar ratio of adenosine monophosphate, VOSO4 and amino acids (AA n ). Results: The magnetic moments and electronic spectra revealed the square pyramidal geometrical structure of the complexes. In an in vivo study, the insulin levels, blood glucose levels, lipid profiles and histology of the pancreas and liver of the animals treated with the complexes were similar to those of healthy control animals, unlike the untreated and vanadyl sulfate(II)–treated diabetic ones. Conclusion: The data gathered in the current research illustrated that vanadyl(II)-AMP-amino acid (AA) mixed-ligand complexes can function as antidiabetic agents.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0471

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