Ruthenium dendrimers against acute promyelocytic leukemia: in vitro studies on HL-60 cells-Reference-Cited by-同舟云学术

Ruthenium dendrimers against acute promyelocytic leukemia: in vitro studies on HL-60 cells

Published:2019-07 Issue:14 Volume:11 Page:1741-1756
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Michlewska Sylwia¹²,Ionov Maksim²,Maroto-Díaz Marta³⁴,Szwed Aleksandra²,Ihnatsyeu-Kachan Aliaksei⁵⁶,Abashkin Viktar⁷,Dzmitruk Volha⁷,Rogalska Aneta⁸,Denel Marta⁶,Gapinska Magdalena¹,Shcharbin Dzmitry⁷,Gomez Ramirez Rafael³⁴⁹,de la Mata Francisco Javier³⁴⁹,Bryszewska Maria²

Affiliation:

1. Laboratory of Microscopic Imaging & Specialized Biological Techniques, Faculty of Biology & Environmental Protection, University of Lodz, Banacha12/16, Lodz 90–237, Poland

2. Department of General Biophysics, Faculty of Biology & Environmental Protection, University of Lodz, Pomorska 141/143, Lodz 90–236, Poland

3. Networking Research Center on Bioengineering, Biomaterials & Nanomedicine (CIBER-BBN), Monforte de Lemos 3-5, Pabellón 11, Planta 028029, Madrid, Spain

4. Departamento Química Orgánica y Química Inorganica, Instituto de Investigación Química ‘Andrés M. del Río’ (IQAR), UAH, Spain

5. Center for Theragnosis, Biomedical Research Institute, Korea Institute of Science & Technology, Seoul 02792, Korea

6. Division of Bio-Medical Science & Technology, KIST School, Korea University of Science & Technology, Seoul 02792, Korea

7. Institute of Biophysics & Cell Engineering of NASB, Akademicheskaja 27, Minsk 220072, Belarus

8. Department of Medical Biophysics, Faculty of Biology & Protection, University of Lodz, Pomorska 141/143, Lodz 90–236, Poland

9. Instituto Ramón y Cajal de Investigación Sanitaria, IRYCIS, Colmenar Viejo Road, Km 9, 100, 28034, Madrid, Spain

Abstract

Coordination of ruthenium arene fragments on carbosilane dendrimers’ surface greatly increases their antitumor properties. Newly synthetized ruthenium dendrimers are water-soluble, monodisperse and stable. Since carbosilane dendrimers are good carriers of drugs and genes, the presence of ruthenium in their structure makes them promising candidates for new drug delivery systems with improved antitumor potential. Carbosilane ruthenium dendrimers are more toxic to cancer cells than normal cells. Results of several in vitro studies applied here indicate that carbosilane ruthenium dendrimers induce apoptosis in promyelocytic leukemia HL-60 cells.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0274

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