The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy-Reference-Cited by-同舟云学术

The lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy

Published:2018-12 Issue:23 Volume:10 Page:2685-2693
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Woźniak Paweł¹,Kontek Bogdan²,Różański Waldemar¹,Olas Beata²

Affiliation:

1. 2nd Department of Urology, Medical University of Łódź, Pabianicka 62, 93-513 Łódź, Poland

2. Department of General Biochemistry, Faculty of Biology & Environmental Protection, University of Łódź, Pomorska 141/3, 90-236 Łódź, Poland

Abstract

Aim: To evaluate the level of lipid peroxidation in patients with nephrolithiasis before and after extracorporeal shock wave lithotripsy (ESWL). Materials & methods: Isoprostane concentration (8-isoPGF2α) was measured in urine, and thiobarbituric acid reactive substance production in serum and erythrocytes. In addition, the concentrations of selected compounds (uric acid, glucose and creatinine) were measured in serum. Results: The patients (before and after ESWL) demonstrated significantly higher levels of two different biomarkers of lipid peroxidation compared with the control group. A correlation was identified between increased amounts of uric acid and biomarkers of lipid peroxidation in patients with nephrolithiasis, both before and after ESWL. Conclusion: Uric acid may be associated with lipid peroxidation in patients with nephrolithiasis.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc-2018-0149

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