tRNA modification and cancer: potential for therapeutic prevention and intervention-Reference-Cited by-同舟云学术

tRNA modification and cancer: potential for therapeutic prevention and intervention

Published:2019-04 Issue:8 Volume:11 Page:885-900
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Endres Lauren¹,Fasullo Michael²,Rose Rebecca³

Affiliation:

1. State University of New York Polytechnic Institute, College of Arts & Sciences, Utica, NY, USA

2. State University of New York Polytechnic Institute, College of Nanoscale Science & Engineering, Albany, NY, USA

3. Metabolomics Core Resource Laboratory, NYU Langone Health, New York, NY, USA

Abstract

Transfer RNAs (tRNAs) undergo extensive chemical modification within cells through the activity of tRNA methyltransferase enzymes (TRMs). Although tRNA modifications are dynamic, how they impact cell behavior after stress and during tumorigenesis is not well understood. This review discusses how tRNA modifications influence the translation of codon-biased transcripts involved in responses to oxidative stress. We further discuss emerging mechanistic details about how aberrant TRM activity in cancer cells can direct programs of codon-biased translation that drive cancer cell phenotypes. The studies reviewed here predict future preventative therapies aimed at augmenting TRM activity in individuals at risk for cancer due to exposure. They further predict that attenuating TRM-dependent translation in cancer cells may limit disease progression while leaving noncancerous cells unharmed.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0404

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