Analysis of 8q24.21 miRNA cluster expression and copy number variation in gastric cancer-Reference-Cited by-同舟云学术

Analysis of 8q24.21 miRNA cluster expression and copy number variation in gastric cancer

Published:2019-05 Issue:9 Volume:11 Page:947-958
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Anauate Ana C¹,Leal Mariana F¹,Wisnieski Fernanda¹²,Santos Leonardo C¹,Gigek Carolina O¹³,Chen Elizabeth S¹,Calcagno Danielle Q⁴,Assumpção Paulo P⁴,Demachki Sâmia⁴,Arasaki Carlos H³,Artigiani Ricardo⁵,Rasmussen Lucas T⁶,Payão Spencer M⁶,Burbano Rommel R⁴⁷⁸,C Smith Marília A¹

Affiliation:

1. Disciplina de Genética, Departamento de Morfologia e Genética, Universidade Federal de São Paulo, São Paulo, 04023-900, Brazil

2. Disciplina de Gastroenterologia, Departamento de Medicina, Universidade Federal de São Paulo, São Paulo, 04040-002, Brazil

3. Disciplina de Gastroenterologia Cirúrgica, Departamento de Cirurgia, Universidade Federal de São Paulo, São Paulo, 04024-002, Brazil

4. Núcleo de Pesquisas em Oncologia, Hospital Universitário João de Barros Barreto, Universidade Federal do Pará, Belém, 66073-000, Brazil

5. Departamento de Patologia, Universidade Federal de São Paulo, São Paulo, 04023-062, Brazil

6. Departamento de Genética e Biologia Molecular, Faculdade de Medicina de Marília, Marília, 17519-050, Brazil

7. Laboratório de Citogenética Humana, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém, 66075-110, Brazil

8. Laboratório de Biologia Molecular, Hospital Ophir Loyola, Belém, 66063-240, Brazil

Abstract

Aim: To analyze gene expression and copy number of five miRNAs ( miR-1204, miR-1205, miR-1206, miR-1207 and miR-1208) localized in this chromosome region in gastric cancer (GC). Materials & methods: 65 paired neoplastic and non-neoplastic specimens collected from GC patients and 20 non-neoplastic gastric tissues from cancer-free individuals were included in this study. The expression levels of the five miRNAs were accessed by real time qPCR and were correlated. Results: MiR-1207-3p, miR-1205, miR-1207-5p and miR-1208 were upregulated in approximately 50% of GC tumors in relation to those of adjacent non-neoplastic tissues. MiR-1205 expression was associated with gain of gene copies and was upregulated in adjacent non-neoplastic samples relative to external controls. Conclusion: The coexpression of the 8q24 miRNAs indicated the role of miR-1205 in the initiation of gastric cancer development.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

https://www.future-science.com/doi/pdf/10.4155/fmc-2018-0477

Reference51 articles.

1. WHO. World health statistics (2015). www.who.int/

2. Gastric cancer epidemiology and risk factors

3. Genetics of gastric cancer

4. Numerical aberrations of chromosome 8 detected by conventional cytogenetics and fluorescence in situ hybridization in individuals from northern Brazil with gastric adenocarcinoma

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