In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis-Reference-Cited by-同舟云学术

In vitro antiprotozoal activity of some medicinal plants against sleeping sickness, Chagas disease and leishmaniasis

Published:2018-11 Issue:22 Volume:10 Page:2607-2617
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Okba Mona M¹,Sabry Omar M¹,Matheeussen An²,Abdel-Sattar Essam¹

Affiliation:

1. Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Kasr El-Ainy Street, Cairo, 11562, Egypt

2. Laboratory for Microbiology, Parasitology & Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical & Veterinary Sciences, Antwerp University, B-2610 Wilrijk-Antwerp, Belgium

Abstract

Aim: Antiprotozoal activity of 36 medicinal plants was evaluated. Materials & methods: In vitro potency against Trypanosoma brucei brucei, T. b. rhodesiense, T. cruzi and Leishmania infantum beside cytotoxicity on MRC-5 fibroblasts were determined. Results & conclusion: Maytenus parviflora showed the highest activity against T. b. brucei (IC50 of 0.6 μg/ml) and T. b. rhodesiense (IC50 of 0.5 μg/ml) with low cytotoxicity (CC50 of 30 μg/ml). Saussurea costus and Commiphora wightii, showed pronounced potency against T. cruzi with an IC50 of 3.6 and 2.5 μg/ml, respectively. Jatropha pelargonifolia and Solanum villosum exhibited pronounced activity toward L. infantum with an IC50 of 3.2 and 2.0 μg/ml, respectively. M. parviflora, S. costus, C. wightii, J. pelargonifolia and S. villosum showed relevant selectivity.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc-2018-0180

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