Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood

Nanodelivery systems for overcoming limited transportation of therapeutic molecules through the blood–brain barrier

Published:2018-11 Issue:22 Volume:10 Page:2659-2674
ISSN:1756-8919
Container-title:Future Medicinal Chemistry
language:en
Short-container-title:Future Medicinal Chemistry

Author:

Kim Ki-Taek¹²,Lee Han Sol³,Lee Jeong-Jun³,Park Eui Kyun⁴,Lee Bong-Seon⁵,Lee Jae-Young³,Bae Jong-Sup⁵

Affiliation:

1. College of Pharmacy & Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 08826, Republic of Korea

2. Drug Design, Development, & Delivery (4D) Laboratory, Department of Bioengineering, Clemson University, Clemson, SC 29634, USA

3. College of Pharmacy, Chungnam National University, Daejeon 34134, Republic of Korea

4. Department of Pathology & Regenerative Medicine, School of Dentistry, Kyungpook National University, Daegu 41940, Republic of Korea

5. College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, BK21 Plus KNU Multi-Omics Based Creative Drug Research Team, Kyungpook National University, Daegu 41566, Republic of Korea

Abstract

Due to the impermeable structure and barrier function of the blood–brain barrier (BBB), the delivery of therapeutic molecules into the CNS is extremely limited. Nanodelivery systems are regarded as the most effective and versatile carriers for the CNS, as they can transport cargo molecules across the BBB via various mechanisms. This review emphasizes the multi-functionalization strategies of nanodelivery systems and combinatorial approaches for the delivery of therapeutic drugs and genes into the CNS. The characteristics and functions of the BBB and underlying mechanisms of molecular translocation across the BBB are also described.

Publisher

Future Science Ltd

Subject

Drug Discovery,Pharmacology,Molecular Medicine

Link

http://www.future-science.com/doi/pdf/10.4155/fmc-2018-0208

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