A new approach to bioanalysis: aqueous normal-phase chromatography with silica hydride stationary phases-Reference-Cited by-同舟云学术

A new approach to bioanalysis: aqueous normal-phase chromatography with silica hydride stationary phases

Published:2012-04 Issue:7 Volume:4 Page:845-853
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Pesek Joseph J¹,Matyska Maria T²

Affiliation:

1. Department of Chemistry, San Jose State University, San Jose, CA 95192, USA.

2. Department of Chemistry, San Jose State University, San Jose, CA 95192, USA

Abstract

Stationary phases based on silica hydride have demonstrated a number of unique properties that are especially advantageous for bioanalyses. They have excellent retention capabilities for hydrophilic compounds, which have been the most difficult to analyze by standard reversed-phase methods and, in many cases, can outperform newer approaches for the analysis of polar molecules, such as hydrophilic liquid interaction chromatography. In addition, all columns utilizing silica-hydride materials can be used in either the normal-phase or reversed-phase modes, sometimes retaining both polar and nonpolar compounds simultaneously. These stationary phases have a high degree of reproducibility and long-term stability.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.12.39

Reference35 articles.

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5. Hydrophilic interaction chromatography

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