Affiliation:
1. Department of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Abstract
The lack of an effective method of drug delivery has been a considerable obstacle in the development of novel therapeutics for inner ear diseases. However, several strategies have been investigated to achieve drug delivery to the inner ear, particularly for local application. Here, we review recent advances in the development of inner ear drug-delivery systems, focusing on biodegradable materials. Both synthetic and natural biodegradable materials have shown efficacy for inner ear drug delivery, resulting in an attenuation of hearing loss in animal models. We expect the further development of such drug-delivery systems to help translate the findings of experimental studies to clinical applications.
Reference76 articles.
1. Profound Deafness in Childhood
2. SprinzlGM, Riechelmann H. Current trends in treating hearing loss in elderly people: a review of the technology and treatment options – a mini-review.Gerontology56(3),351–358 (2010).
3. LibermanMC, Rosowski JJ, Lewis RF. Cochlear function and dysfunction. In:Schuknecht’s Pathology of the Ear (Third Edition).Merchant SN, Nadol JB (Eds). People’s Medical Publishing House, CT, USA104–127 (2010).
4. MerchantSN. Degeneration of auditory and vestibular end organs. In:Schuknecht’s Pathology of the Ear (Third Edition).Merchant SN, Nadol JB (Eds). People’s Medical Publishing House, CT, USA,631–663 (2010).
5. Inner ear protection and regeneration: a ‘historical’ perspective
Cited by
19 articles.
订阅此论文施引文献
订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献