A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit-Reference-Cited by-同舟云学术

A device for dried blood microsampling in quantitative bioanalysis: overcoming the issues associated blood hematocrit

Published:2015-04 Issue:6 Volume:7 Page:653-659
ISSN:1757-6180
Container-title:Bioanalysis
language:en
Short-container-title:Bioanalysis

Author:

Spooner Neil¹,Denniff Philip¹,Michielsen Luc²,De Vries Ronald²,Ji Qin C³,Arnold Mark E³,Woods Karen⁴,Woolf Eric J⁵,Xu Yang⁵,Boutet Valérie⁶,Zane Patricia⁷,Kushon Stuart⁸,Rudge James B⁹

Affiliation:

1. Bioanalytical Science & Toxicokinetics, Drug Metabolism & Pharmacokinetics, GlaxoSmithKline Research & Development, Ware, UK

2. Bioanalysis Department, Janssen Research & Development, Turnhoutseweg 30, 2340 Beerse, Belgium

3. Bioanalytical Science & Selective Integration, Bristol-Myers Squibb, Co., Princeton, NJ 08543, USA

4. Pre Clinical Bioanalysis & Toxicokinetics AstraZeneca, Alderley Park, UK

5. Merck Research Laboratories, PPDM-Global Bioanalytics, WP 75B-300, West Point, PA 19486, USA

6. Sanofi Recherche & Developpement, 3 digue d'Alfortville, Bâtiment Claude Bernard, 94140, Alfortville, France

7. Sanofi, 55 Corporate Drive, Bridgewater, NJ 08807, USA

8. Neoteryx, LLC, 421 Amapola Avenue, Torrance, CA 90501, USA

9. Phenomenex, 411 Madrid Avenue, Torrance, CA 90501, USA

Abstract

Aims: A cross-laboratory experiment has been performed on a novel dried blood sampler in order to investigate whether it overcomes issues associated with blood volume and hematocrit (HCT) that are observed when taking a subpunch from dried blood spot samples. Materials & methods: An average blood volume of 10.6 μl was absorbed by the samplers across the different HCTs investigated (20–65%). Results: No notable change of volume absorbed was noted across the HCT range. Furthermore, the variation in blood sample volumes across six different laboratories was within acceptable limits. Conclusion: The novel volumetric absorptive microsampling device has the potential to deliver the advantages of dried blood spot sampling while overcoming some of the issues associated with the technology.

Publisher

Future Science Ltd

Subject

Medical Laboratory Technology,Clinical Biochemistry,General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Analytical Chemistry

Link

http://www.future-science.com/doi/pdf/10.4155/bio.14.310

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